Endocrine Abstracts

Background: Bone metabolism is affected in hemodialysed patients (HD) and PTH plays central role. Additionally leptin which is increased in renal failure may be linked with bone metabolism. We investigated the BMD and bone metabolism in comparison with serum PTH, 25OHD3 and leptin in HD patients.Methods: We measured in 37 HD patients bone alkaline phosphatase (bSAP), NTx, PTH, 25OHD3 and leptin. We evaluated BMI and BMD in lumbar spine (LS) and in femora...

Introduction: Primary hyperparathyroidism causes accelerated bone turnover and the consensus is to measure and act upon the 25hydroxyvitamin D level in order to reduce the drive to PTH production, slow down BMD loss, and prevent hungry bone syndrome. How best to replace vitamin D is less clear so we chose to audit our current practice.Method: In 12 months 120 patients with primary hyperparathyroidism were identified retrospectively, 98 of which were vita...

Background: Insulin like growth factor-2 (IGF-2) has structural similarity to insulin1. In excess, IGF-2 can activate glucose metabolism so precipitating hypoglycaemia1.Case Presentation: Six days following her second dose of Doxorubicin and Olaratumab therapy for a pelvic sarcoma, HS presented with two successive days of acute confusion secondary to documented hypoglycaemia (blood sugars 2.0-3.1 mmol/l, 36-55.8 mg/dl). Despite treatment, she had recurre...

Background: The Chronic Care Model (CCM), developed by Wagner et al., at MacColl Institute for Heathcare Innovation at Group Health Research Institute, Seattle, Washington, United States, is one approach to improving chronic illness care, including diabetes mellitus (DM), that is being used increasingly to assess and improve care. The CCM is based on evidence-based practices and reviews of the literature on effective care. The Patient Assessment of Chronic Illnes...

Introduction: Lymphocytic hypophysitis is an uncommon autoimmune disease usually presenting during or just after pregnancy. It may be followed by panhypopituitarism. In such case is extremely rare for a woman to have a normal delivery again.Case report: We report the case of a 28-year-old woman who had a successful delivery 2 years after lymphocytic hypophysitis which had resulted in panhypopituitarism. The young woman presented with amenorrhea, symptoms...

Prostate cancer (PCa) is one the leading causes of cancer-related deaths among men in developed countries. Therefore, identification of novel molecular and therapeutic approaches to tackle this pathology are urgently needed. In this scenario, our group has recently reported that elements of the cellular machinery controlling alternative splicing processes might be used as potential novel therapeutic tools against PCa and castration-resistant PCa (CRPC). In this context, RBM22 ...

Prostate cancer (PCa) represents the most diagnosed tumour pathology in developed countries among men population. The main pharmacological approach to treat this pathology is based on the blockade of the androgen receptor signalling pathway, commonly known as androgen-deprivation therapy. However, some of the patients does no longer respond to this therapy, therefore developing castration-resistant prostate cancer (CRPC), the most aggressive phenotype of this pathology, which ...

Somatostatin (SST)-system is a pleiotropic hormonal system composed by several ligands/receptors that is involved in the regulation of multiple pathophysiological functions. Specifically, certain components of the SST-system are dysregulated in several endocrine-related cancer types compared to control tissues, wherein these alterations seem to influence their development/progression. However, the presence and functional role of neuronostatin (NST) and its putative G-protein c...

Background: Diabetes mellitus is mainly characterized by a dysfunction of glucose metabolism. The growth of diabetes mellitus as a chronic condition requires continuous management and requires health services to implement care strategies. Diabetes education and self-care competence have been recognized over the last few decades as essential for patients with diabetes mellitus to achieve positive treatment results.Objective: To compare self-care competenc...

Background: Up to 15% of pheochromocytomas are malignant. The only definite criterion for malignancy is the presence of metastases. The histological differentiation between benign and malignant tumours is difficult, being a challenging problem nowadays.Aim: To asses if postoperative histological evaluation using the previously proposed pheochromocytoma of the adrenal gland scales scored (PASS) can predict malignancy.Methods: Twenty...